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If this is likely to occur, the exposures should be meas-ured during follow-up (called longitudinal cohort study)

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Nicotine caused significantly reduced yields ofDHT due to down-regulation of 5?-reductase activity, which was overcome by theantioxidant glutathione indicative of modulation of the pro-oxidant effects of nicotine byGSH.

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American Academy of Pediatrics Committee on Drugs.

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